Bioactive Small Molecules
Cayman Chemical RN-18, Purity: ≥98%, CAS: 431980-38-0, 1 mg
An HIV-1 Vif inhibitor; inhibits Vif-mediated degradation of the DNA editing enzyme APOBEC3G (IC50s = 10-30 µM); inhibits HIV-1 viral replication (IC50s = 4.5 and 10 µM for nonpermissive CEM and H9 cells, respectively, and >100 µM for permissive cells)
Medchemexpress LLC Methylthio-DADMe-Immucillin A | 653592-04-2 | MFCD30738019 | 98.4% | 293.40 g/mol | C13H19N5OS | 100 MG
MT-DADMe-ImmA is a potent, selective inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) supplied as a white to off-white solid for laboratory research. It exhibits subnanomolar affinity (Ki ≈ 90 pM) and is supplied in milligram-scale packages appropriate for biochemical and cellular studies.
- Potent MTAP inhibition with Ki ≈ 90 pM.
- High purity (≈98.4%).
- Molecular formula C13H19N5OS; molecular weight 293.40 g/mol.
- White to off-white solid suitable for biochemical assays.
- Available in small milligram package sizes for research use.
- Recommended storage: powder -20°C for long-term stability.
TARGETMOL CHEMICALS INC PRT4165 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor. purity: 99%
Cayman Chemical 3,4-Methylenedioxy-N-benzylcathinone (hydrochloride), Purity: ≥98%, CAS: 1823274-68-5, 5 mg
A substituted cathinone that is structurally analogous to methylone, a narcotic which is regulated in the United States; intended for research and forensic applications
Medchemexpress LLC DSPE-PEG-biotin | 385437-57-0 | 99.9% | C142H280N5O56PS | 10MG
DSPE-PEG-Biotin (average molecular weight 2000) is an amphiphilic lipid-polyethylene glycol conjugate bearing a terminal biotin. It enables incorporation of biotin functionality into lipid assemblies, liposomes, micelles, and biomolecules for affinity capture, surface functionalization, and use as a PEG-based linker in conjugation chemistries.
- Amphiphilic lipid-PEG conjugate enabling membrane incorporation.
- Terminal biotin enables strong binding to streptavidin and avidin.
- Average molecular weight 2000 and high purity suitable for conjugation.
- Soluble in DMSO (25 mg/mL) and dispersible in water (5 mg/mL) with ultrasonic aid.
- Stable as a powder at -20°C; solvent stability is limited.
- Useful for liposome functionalization, affinity capture, and linker synthesis in bioconjugation.
Medchemexpress LLC HY-131339 5mg Medchemexpress, SP-96 CAS: Purity:>98%
Medchemexpress, HY-131339 5mg SP-96 CAS: SP-96 is a highly potent, selective and non-ATP-competitive Aurora B (IC50=0.316 nM) inhibitor and shows >2000 fold selectivity against FLT3 and KIT. SP-96 shows selective growth inhibition in NCI60 screening, incluing MDA-MD-468 (GI50=107 nM). SP-96 can be used for the research of triple negative breast cancer (TNBC). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC IgG1 Protein Human 500ug
Recombinant human IgG1 protein (D239E, L241E) is the Fc constant region expressed in HEK293 cells and supplied tag-free. It is intended for use in immunology and biochemical assays that require the human IgG1 Fc domain, and can support studies of Fc receptor binding and assay development.
- Recombinant human IgG1 Fc region with D239E and L241E mutations.
- Expressed in HEK293 mammalian cells.
- Tag free format for native Fc studies.
- Suitable for immunology and biochemical assay development.
- Useful for Fc receptor interaction and binding studies.
Medchemexpress LLC DIM-C-pPhCO2Me | 151358-48-4 | 99.5% | 380.44 | 50 MG
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist that induces apoptosis and decreases various proteins including PAX3-FOXO1A, N-Myc, Rassf4, MyoD1, Grem1, and DAPK1. It also reduces TXNDC5 and IDH1 expression, while inducing ER stress markers (CHOP, ATF4, and p-PERK). This compound inhibits renal cell carcinoma and breast cancer, and is useful in rhabdomyosarcoma research.
- Induces apoptosis
- Decreases PAX3-FOXO1A, N-Myc, Rassf4, MyoD1, Grem1, and DAPK1 proteins
- Reduces TXNDC5 and IDH1 expression
- Induces markers of ER stress
- Inhibits renal cell carcinoma
- Inhibits breast cancer
- Useful in rhabdomyosarcoma research
Medchemexpress LLC PROTAC KRAS G12D degrader 1 | 3033583-54-6 | 98.3% | 1103.33 | 50 MG
PROTAC KRAS G12D degrader 1 is a selective PROTAC KRASG12D degrader that inhibits proliferation of KRASG12D-mutant cells and suppresses ERK phosphorylation. It inhibits tumor growth in mice bearing AsPC-1 xenografts and can be used for the study of KRASG12D-driven cancers.
- Selective PROTAC KRASG12D degrader.
- Inhibits proliferation of KRASG12D-mutant cells.
- Suppresses ERK phosphorylation.
- Inhibits tumor growth in mice bearing AsPC-1 xenografts.
- Can be used for the study of KRASG12D-driven cancers.
- Dose-dependently degrades KRASG12D in SNU-1, HPAF-II, AGS, and PANC 04.03 cells.
- Significantly decreases KRASG12D protein level in AsPC-1 cells.
- Leads to sustained KRASG12D degradation and pERK inhibition in AsPC-1 cells.
- Reduced KRASG12D protein level and phosphorylation level of ERK in AsPC-1 xenograft tumor tissues.
- Downregulated the mRNA level of DUSP4.
Medchemexpress LLC N-desmethyl diltiazem hydrochloride | 130606-60-9 | 10mg
N-Desmethyl diltiazem hydrochloride is a substrate for CYP3A7 metabolism which is the predominant fetal form and is minimally expressed in adults[1]
Cayman Chemical SIB 1757, Purity: ≥95%, CAS: 31993-01-8, 25 mg
An antagonist of mGluR5a; selectively inhibits glutamate-induced calcium release and quisqualate-induced phosphoinositol accumulation in fibroblasts expressing human mGluR5a (IC50s = 0.37 and 3.1 µM, respectively) over mGluR1b-expressing fibroblasts (IC50s = >100 µM for both); selective for mGluR5a over mGluR2, mGluR3, mGluR4a, mGluR6, mGluR7b, mGluR8 (IC50s = >100 µM for all) as well as AMPA, kainate, and NMDA receptors (IC50s = >30 µM for all); inhibits (S)-3,5-DHPG-induced phosphoinositol accumulation in isolated neonatal rat hippocampus and striatum (IC50s = 5.2 and 10.1 µM, respectively); intrathecal administration increases the paw withdrawal threshold in a rat model of spinal nerve ligation-induced neuropathic pain at 0.01 µg/animal
Cayman Chemical AC-262536, Purity: ≥98%, CAS: 870888-46-3, 5 mg
A SARM (Ki = 5.01 nM); an androgen receptor partial agonist (EC50 = 1.58 nM in a luciferase assay); selective for the androgen receptor over a panel of 47 additional human nuclear receptors at 10 µM; inhibits dihydroxytestosterone-induced proliferation of LNCaP prostate cancer cells at 0.1 and 1 µM; reduces plasma luteinizing hormone levels and increases levator ani muscle weight in castrated rats at 3, 10, and 30 mg/kg; exhibits smaller increases in prostate gland and seminal vesicle weight compared with testosterone in the same model
Medchemexpress LLC Akt kinase inhibitor hydrochloride | 3026697-00-4 | MFCD34676556 | 99.4% | 393.83 g/mol | C16H20ClN7O3 | 10 MG
AKT Kinase Inhibitor (hydrochloride) is a small-molecule Akt pathway inhibitor supplied for research use. Provided as the hydrochloride salt, it is used in biochemical and cellular assays to inhibit Akt kinase activity and study signaling and oncology-related pathways.
- High reported purity (99.4%).
- Molecular weight 393.83 g/mol.
- Soluble in DMSO and water (DMSO 3.33 mg/mL; H2O 20 mg/mL).
- Supplied in milligram-scale quantities suitable for assay development and in vitro studies.
- Refrigerated storage recommended per supplier guidance.
Medchemexpress LLC FlAsH-EDT2 | 212118-77-9 | MFCD27977924 | ≥99.0% | 664.50 | C24H18As2O5S4 | 5 MG
FlAsH-EDT2 is a membrane-permeant biarsenical fluorescent probe for selective labeling of proteins containing tetracysteine (Cys4) motifs. It binds tetracysteine sequences with high affinity and becomes highly fluorescent upon binding, making it suitable for live-cell imaging, protein localization, and tracking studies.
- Membrane-permeant probe for live-cell labeling.
- Binds tetracysteine (Cys4) motifs with high affinity.
- Fluoresces strongly upon binding, enabling sensitive detection.
- Compatible with fluorescence microscopy and protein tracking.
- Available in small milligram pack sizes for research use.
- High purity suitable for biological assays.
Medchemexpress LLC GNE-317 | 1394076-92-6 | 98.8% | 100 MG
GNE-317 is a PI3K/mTOR inhibitor that can cross the blood-brain barrier (BBB). It is an oxetane derivative of GDC-0980, synthesized to reduce substrate affinity for efflux transporters. While GNE-317 shows greater delivery and enhanced therapeutic targeting efficacy compared to GDC-0980, it showed limited efficacy in inducing cell death in GL261 cell lines in vitro and was not found effective in vivo in GL261 tumor models.
- PI3K/mTOR inhibitor
- Can cross the blood-brain barrier (BBB)
- Oxetane derivative
- Greater delivery and enhanced therapeutic targeting efficacy